Prostate Cancer Treatment Comparisons

Posted by Jay Rolls on March 24th, 2014 — Posted in General

This just in from the UF Proton Therapy Institute – I’ve coped their table below. As they state:

“Part of the decision-making process is to learn each treatment’s potential for cure (disease control) and for maintaining a good quality of life after treatment. The following table shows the most current prostate cancer patient outcomes data available for both proton therapy and surgery.”

Thanks to my old flight instructor “Doc” Harkins for passing this along…….

Decision Points Proton Therapy for Prostate Cancer Surgery for Prostate Cancer
Disease Control* 99%-76%1 84%-60%2,3
Treatment
Major complication rate 1%1** 28.6%4
Invasive Procedure No Yes
Long Recovery Time No Yes
Fatigue No Yes
30-day mortality rate 0% 0.5%4
Rehospitalization rate 0% (N/A) 4.5%4
Side Effects
Percent of patients who experience a change post treatment
Incontinence 0%1 6%-30%4
Impotence 34%1 60%-80%1
Inguinal hernia 0% (N/A) 7%-21%4
Fecal Incontinence 1.4%1 17%-32%5

*Disease control is defined as freedom from clinical or PSA progression at five years.

**1% per Common Terminology Criteria for Adverse Events (CTCAE) v4.0; 5.3% per CTCAE v3.0

1.Mendenhall, NP et al. Five-Year Outcomes from 3 Prospective Trials of Image-Guided Proton Therapy for Prostate Cancer. Int J Radiation Oncol Biol Phys 2014 March; 88(3):596-602.

2.Han, M et al. Long-Term Biochemical Disease-Free and Cancer-Specific Survival Following Anatomic Radical Retropubic Prostatectomy: The 15-Year Johns Hopkins Experience. Urol Clin North Am 2001 Aug; 28(3):555-65.

3.Qi, P et al. Long-Term Oncological Outcomes of Men Undergoing Radical Prostatectomy With Preoperative Prostate-Specific Antigen <2.5 ng/ml and 2.5-4 ng/ml. Urol Oncol 2013 Nov; 31(8):1527-32.

4.Treatment Option Overview for Prostate Cancer, Health Professional Version. Retrieved Aug. 28, 2013.

5.Bishoff JT et al. Incidence of fecal and urinary incontinence following radical perineal and retropubic prostatectomy in a national population. J Urol 160 (2): 454-8, 1998.

3.7.14 Reviewed by Nancy P. Mendenhall, M.D.

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